The global curcumin market was valued at $58.4 million in 2019 and is projected to reach $104.19 million by 2025. The reason for the selection of curcumin for this study is, it is one of the important and thoroughly investigated naturally occurring bioactive compound, but its precise mode of action is still unclear. Curcumin is a yellowish-orange polyphenolic compound of turmeric/haldi ( Curcuma longa), a herb often found in curry powder. Naturally derived compounds possess enormous potential for medicinal and therapeutic actions for the management of diseases and curcumin is one of the most suitable examples among them. This comprehensive in-silico study will help to understand how curcumin induces its anti-cancerous, anti-inflammatory, and anti-microbial effects in the human body. The current findings deduce a precise molecular mechanism that curcumin might exert in the system. Finally, the analysis of topological characteristic like bottleneck, degree, GO term/pathways analysis, bio-kinetics simulation, molecular docking, and dynamics studies were performed for the selection of key regulatory proteins of curcumin-rewired PIN. Most of them were associated with human diseases groups, particularly carcinogenesis, inflammation, and infectious diseases. MCODE plug-in was used for sub-modulization analysis, wherein we identified 25 modules ClueGo plug-in was used for the pathway’s enrichment analysis, wherein 37 enriched signalling pathways were obtained. The PIN rewired by curcumin was a scale-free, extremely linked biological system. To identify the curcumin governed regulatory action on protein interaction network (PIN), an interectome was created based on 788 key proteins, extracted from PubMed literatures, and constructed by using STRING and Cytoscape programs. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively.
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